BCL-2 inhibition targets oxidative phosphorylation and selectively eradicates quiescent human leukemia stem cells

Most forms of chemotherapy employ mechanisms involving induction of oxidative stress, a strategy that can be effective due to the elevated oxidative state commonly observed in cancer cells. However, recent studies have shown that relative redox levels in primary tumors can be heterogeneous, suggesti...

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Hlavní autoři: Lagadinou, Eleni D., Sach, Alexander, Callahan, Kevin, Rossi, Randall M., Neering, Sarah J., Minhajuddin, Mohammad, Ashton, John M., Pei, Shanshan, Grose, Valerie, O’Dwyer, Kristen M., Liesveld, Jane L., Brookes, Paul S., Becker, Michael W., Jordan, Craig T.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2013
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3595363/
https://ncbi.nlm.nih.gov/pubmed/23333149
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2012.12.013
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