HIV-1 Receptor Binding Site-Directed Antibodies Using a VH1-2 Gene Segment Orthologue Are Activated by Env Trimer Immunization

Broadly neutralizing antibodies (bNAbs) isolated from chronically HIV-1 infected individuals reveal important information regarding how antibodies target conserved determinants of the envelope glycoprotein (Env) spike such as the primary receptor CD4 binding site (CD4bs). Many CD4bs-directed bNAbs u...

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Main Authors: Navis, Marjon, Tran, Karen, Bale, Shridhar, Phad, Ganesh E., Guenaga, Javier, Wilson, Richard, Soldemo, Martina, McKee, Krisha, Sundling, Christopher, Mascola, John, Li, Yuxing, Wyatt, Richard T., Karlsson Hedestam, Gunilla B.
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2014
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4148451/
https://ncbi.nlm.nih.gov/pubmed/25166308
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1004337
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