Glutaraldehyde Cross-linking of HIV-1 Env Trimers Skews the Antibody Subclass Response in Mice

Well-ordered soluble HIV-1 envelope glycoprotein (Env) spike mimetics such as Native Flexibly Linked (NFL) trimers display high homogeneity, desired antigenicity, and high in vitro stability compared to previous generation soluble HIV-1 Env trimers. Glutaraldehyde (GLA) cross-linking was shown to fu...

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Detalles Bibliográficos
Publicado en:Front Immunol
Main Authors: Soldemo, Martina, Àdori, Monika, Stark, Julian M., Feng, Yu, Tran, Karen, Wilson, Richard, Yang, Lifei, Guenaga, Javier, Wyatt, Richard T., Karlsson Hedestam, Gunilla B.
Formato: Artigo
Idioma:Inglês
Publicado: Frontiers Media S.A. 2017
Assuntos:
Immunology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5711779/
https://ncbi.nlm.nih.gov/pubmed/29230223
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2017.01654
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