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Ebolavirus VP35 suppresses IFN production from conventional but not plasmacytoid dendritic cells

Ebolaviruses naturally infect a wide variety of cells including macrophages and dendritic cells, and the resulting cytokine and interferon-α/β responses of infected cells are thought to influence viral pathogenesis. The VP35 protein impairs RIG-I-like receptor dependent signaling to inhibit interfer...

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Detalhes bibliográficos
Main Authors: Leung, Lawrence W., Park, Man-Seong, Martinez, Osvaldo, Valmas, Charalampos, López, Carolina B., Basler, Christopher F.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4148147/
https://ncbi.nlm.nih.gov/pubmed/21263462
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/icb.2010.169
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