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Identification of Trisubstituted-pyrazol Carboxamide Analogs as Novel and Potent Antagonists of Farnesoid X Receptor

Farnesoid X receptor (FXR, NRIH4) plays a major role in the control of cholesterol metabolism. This suggests that antagonizing the transcriptional activity of FXR is a potential means to treat cholestasis and related metabolic disorders. Here we describe the synthesis, biological evaluation, and str...

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Главные авторы: Yu, Donna D., Lin, Wenwei, Forman, Barry M., Chen, Taosheng
Формат: Artigo
Язык:Inglês
Опубликовано: 2014
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4147378/
https://ncbi.nlm.nih.gov/pubmed/24775917
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2014.04.014
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