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Development of Time Resolved Fluorescence Resonance Energy Transfer-based Assay for FXR Antagonist Discovery
FXR (farnesoid X receptor, NRIH4), a nuclear receptor, plays a major role in the control of cholesterol metabolism. FXR ligands have been investigated in preclinical studies for targeted therapy against metabolic diseases, but have shown limitations. Therefore, there is a need for new agonist or ant...
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| Главные авторы: | , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2013
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3691817/ https://ncbi.nlm.nih.gov/pubmed/23688559 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2013.04.069 |
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