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Development of Time Resolved Fluorescence Resonance Energy Transfer-based Assay for FXR Antagonist Discovery
FXR (farnesoid X receptor, NRIH4), a nuclear receptor, plays a major role in the control of cholesterol metabolism. FXR ligands have been investigated in preclinical studies for targeted therapy against metabolic diseases, but have shown limitations. Therefore, there is a need for new agonist or ant...
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| 主要な著者: | , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2013
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3691817/ https://ncbi.nlm.nih.gov/pubmed/23688559 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2013.04.069 |
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