Development of Time Resolved Fluorescence Resonance Energy Transfer-based Assay for FXR Antagonist Discovery

FXR (farnesoid X receptor, NRIH4), a nuclear receptor, plays a major role in the control of cholesterol metabolism. FXR ligands have been investigated in preclinical studies for targeted therapy against metabolic diseases, but have shown limitations. Therefore, there is a need for new agonist or ant...

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Hlavní autoři: Yu, Donna D., Lin, Wenwei, Chen, Taosheng, Forman, Barry M.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2013
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3691817/
https://ncbi.nlm.nih.gov/pubmed/23688559
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2013.04.069
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