Novel inhibitors are cytotoxic for myeloma cells with NFkB inducing kinase-dependent activation of NFkB

NFkB activity is critical for survival and proliferation of normal lymphoid cells and many kinds of B-cell tumors, including multiple myeloma (MM). NFkB activating mutations, which are apparent progression events, enable MM tumors to become less dependent on bone marrow signals that activate NFkB. M...

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Autori principali: Demchenko, Yulia N., Brents, Leslie A., Li, Zhihong, Bergsagel, Leif P., McGee, Lawrence R., Kuehl, Michael W.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Impact Journals LLC 2014
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Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4147345/
https://ncbi.nlm.nih.gov/pubmed/24980832
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