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Molecular Imaging of the Efficacy of Heat Shock Protein 90 Inhibitors in Living Subjects

Heat shock protein 90α (Hsp90α)/p23 and Hsp90β/p23 interactions are crucial for proper folding of proteins involved in cancer and neurodegenerative diseases. Small molecule Hsp90 inhibitors block Hsp90α/p23 and Hsp90β/p23 interactions in part by preventing ATP binding to Hsp90. The importance of iso...

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Autors principals: Chan, Carmel T., Paulmurugan, Ramasamy, Gheysens, Olivier S., Kim, Joungnam, Chiosis, Gabriela, Gambhir, Sanjiv Sam
Format: Artigo
Idioma:Inglês
Publicat: 2008
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4146344/
https://ncbi.nlm.nih.gov/pubmed/18172314
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-07-2268
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