Discovery and validation of small-molecule heat-shock protein 90 inhibitors through multimodality molecular imaging in living subjects

Up-regulation of the folding machinery of the heat-shock protein 90 (Hsp90) chaperone protein is crucial for cancer progression. The two Hsp90 isoforms (α and β) play different roles in response to chemotherapy. To identify isoform-selective inhibitors of Hsp90(α/β)/cochaperone p23 interactions, we...

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Autores principales: Chan, Carmel T., Reeves, Robert E., Geller, Ron, Yaghoubi, Shahriar S., Hoehne, Aileen, Solow-Cordero, David E., Chiosis, Gabriela, Massoud, Tarik F., Paulmurugan, Ramasamy, Gambhir, Sanjiv S.
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2012
Materias:
PNAS Plus
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3443147/
https://ncbi.nlm.nih.gov/pubmed/22895790
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1205459109
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