Discovery and validation of small-molecule heat-shock protein 90 inhibitors through multimodality molecular imaging in living subjects

Up-regulation of the folding machinery of the heat-shock protein 90 (Hsp90) chaperone protein is crucial for cancer progression. The two Hsp90 isoforms (α and β) play different roles in response to chemotherapy. To identify isoform-selective inhibitors of Hsp90(α/β)/cochaperone p23 interactions, we...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Chan, Carmel T., Reeves, Robert E., Geller, Ron, Yaghoubi, Shahriar S., Hoehne, Aileen, Solow-Cordero, David E., Chiosis, Gabriela, Massoud, Tarik F., Paulmurugan, Ramasamy, Gambhir, Sanjiv S.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2012
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3443147/
https://ncbi.nlm.nih.gov/pubmed/22895790
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1205459109
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados