Complex IV Deficient Surf1(−/−) Mice Initiate Mitochondrial Stress Responses

Mutations in SURF1 cytochrome c oxidase (COX) assembly protein are associated with Leigh’s syndrome, a human mitochondrial disorder that manifests as severe mitochondrial phenotypes and early lethality. In contrast, mice lacking the Surf1 protein (Surf1(−/−)) are viable and were previously shown to...

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Detalhes bibliográficos
Main Authors: Pulliam, Daniel A., Deepa, Sathyaseelan S., Liu, Yuhong, Hill, Shauna, Lin, Ai-Ling, Bhattacharya, Arunabh, Shi, Yun, Sloane, Lauren, Viscomi, Carlo, Zeviani, Massimo, Van Remmen, Holly
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4145821/
https://ncbi.nlm.nih.gov/pubmed/24911525
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20140291
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