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Rapamycin Modulates Markers of Mitochondrial Biogenesis and Fatty Acid Oxidation in the Adipose Tissue of db/db Mice

Excess nutrient uptake leads to obesity, insulin resistance, and type 2 diabetes. Mammalian target of the rapamycin (mTOR), a major component of the nutrient-sensing pathway also regulates mitochondrial oxidative function. Rapamycin, a pharmacological inhibitor of mTOR, causes glucose intolerance an...

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Detalhes bibliográficos
Main Authors: Deepa, Sathyaseelan S., Walsh, Michael E., Hamilton, Ryan T., Pulliam, Daniel, Shi, Yun, Hill, Shauna, Li, Yan, Van Remmen, Holly
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3760510/
https://ncbi.nlm.nih.gov/pubmed/24010023
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