Metastatic tumor evolution and organoid modeling implicate TGFBR2 as a cancer driver in diffuse gastric cancer

BACKGROUND: Gastric cancer is the second-leading cause of global cancer deaths, with metastatic disease representing the primary cause of mortality. To identify candidate drivers involved in oncogenesis and tumor evolution, we conduct an extensive genome sequencing analysis of metastatic progression...

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Autors principals: Nadauld, Lincoln D, Garcia, Sarah, Natsoulis, Georges, Bell, John M, Miotke, Laura, Hopmans, Erik S, Xu, Hua, Pai, Reetesh K, Palm, Curt, Regan, John F, Chen, Hao, Flaherty, Patrick, Ootani, Akifumi, Zhang, Nancy R, Ford, James M, Kuo, Calvin J, Ji, Hanlee P
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2014
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4145231/
https://ncbi.nlm.nih.gov/pubmed/25315765
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-014-0428-9
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