Metastatic tumor evolution and organoid modeling implicate TGFBR2 as a cancer driver in diffuse gastric cancer

BACKGROUND: Gastric cancer is the second-leading cause of global cancer deaths, with metastatic disease representing the primary cause of mortality. To identify candidate drivers involved in oncogenesis and tumor evolution, we conduct an extensive genome sequencing analysis of metastatic progression...

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Detalhes bibliográficos
Main Authors: Nadauld, Lincoln D, Garcia, Sarah, Natsoulis, Georges, Bell, John M, Miotke, Laura, Hopmans, Erik S, Xu, Hua, Pai, Reetesh K, Palm, Curt, Regan, John F, Chen, Hao, Flaherty, Patrick, Ootani, Akifumi, Zhang, Nancy R, Ford, James M, Kuo, Calvin J, Ji, Hanlee P
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2014
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4145231/
https://ncbi.nlm.nih.gov/pubmed/25315765
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-014-0428-9
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