ONCOLYTIC POLIO/RHINOVIRUS RECOMBINANT (PVSRIPO) IN RECURRENT GLIOBLASTOMA (GBM): FIRST PHASE I CLINICAL TRIAL EVALUATING THE INTRATUMORAL ADMINISTRATION

BACKGROUND: PVSRIPO is the live attenuated, oral (SABIN) serotype 1 poliovirus vaccine containing a heterologous internal ribosomal entry site stemming from human rhinovirus type 2. PVSRIPO recognizes nectin-like molecule-5, an oncofetal cell adhesion molecule and tumor antigen widely expressed ecto...

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Main Authors: Desjardins, Annick, Sampson, John H., Peters, Katherine B., Ranjan, Tulika, Vlahovic, Gordana, Threatt, Stevie, Herndon, James E., Boulton, Susan, Lally-Goss, Denise, McSherry, Frances, Friedman, Allan H., Friedman, Henry S., Bigner, Darell D., Gromeier, Matthias
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2014
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4144655/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nou209.5
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