HIGH INTERSTITIAL FLUID PRESSURE REGULATES TUMOR GROWTH AND DRUG UPTAKE IN HUMAN GLIOBLASTOMA

BACKGROUND: (blind field). METHODS: We developed methodology to measure IFP in human GBM xenografts and mechanical compression in 3D-cultures. We used a cell counter and calcein-AM-loaded cells to measure cell volume following treatment with temozolomide and/or blockade of NKCC1 activity. Fluorescen...

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Hauptverfasser: Persson, Anders I., Ilkhanizadeh, Shirin, Miroshnikova, Yekaterina A., Frantz, Aaron, Lakins, John N., James, C. David, McKnight, Tracy R., Berger, Mitchel S., Bergers, Gabriele, Weiss, William A., Weaver, Valerie M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2014
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4144583/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nou208.37
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