HISTOPATHOLOGIC EVALUATION OF H3K27ME3 IS A PROGNOSTIC BIOMARKER FOR PEDIATRIC GLIOBLASTOMAS

BACKGROUND: Up to 30% of pediatric glioblastomas (GB) demonstrate mutations in H3F3A, a gene variant encoding histone H3.3. Global reduction in H3K27me3 is associated with H3F3A K27M mutation. METHODS: We evaluated the utility of histopathological detection of this reduction in H3K27me3 as a prognos...

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Hauptverfasser: Judkins, Alexander R., Venneti, Sriram, Santi, Mariarita, Felicella, Michelle Madden, Sullivan, Lisa M., Dolgalev, Igor, Martinez, Daniel, Perry, Arie, Lewis, Peter W., Allis, David C., Thompson, Craig B.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2014
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4144571/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nou208.26
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