DISTINCT AND SEPARABLE ROLES FOR HISTONE METHYLTRANSFERASE EZH2 IN NEUROGENIC ASTROCYTES

BACKGROUND: The histone methyltransferase EZH2 is overexpressed in many tumors including gliomas. EZH2 catalyzes H3K27me3, which underlies Polycomb-mediated gene repression, and EZH2-inhibitors have been identified as potential therapeutic agents. In the adult brain subventricular zone (SVZ), a spec...

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Hlavní autoři: Lim, Daniel A., Hwang, William W., Salinas, Ryan D., Siu, Jason J., Kelley, Kevin W., Delgado, Ryan N., Paredes, Mercedes F., Alvarez-Buylla, Arturo, Oldham, Michael C.
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2014
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4144532/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nou206.63
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