Critical role of all-trans retinoic acid in stabilizing human natural regulatory T cells under inflammatory conditions

Recent studies have demonstrated that thymus-derived naturally occurring CD4(+)Foxp3(+) regulatory T cells (Tregs) in human and mouse may be unstable and dysfunctional in the presence of proinflammatory cytokines. All-trans RA (atRA), the active derivative of vitamin A, has been shown to regulate Tr...

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Bibliographic Details
Main Authors: Lu, Ling, Lan, Qin, Li, Zhiyuan, Zhou, Xiaohui, Gu, Jian, Li, Qiang, Wang, Julie, Chen, Maogen, Liu, Ya, Shen, Yi, Brand, David D., Ryffel, Bernhard, Horwitz, David A., Quismorio, Francisco P., Liu, Zhongmin, Li, Bin, Olsen, Nancy J., Zheng, Song Guo
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2014
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PNAS Plus
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4143025/
https://ncbi.nlm.nih.gov/pubmed/25099355
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1408780111
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