All-Trans Retinoic Acid Promotes TGF-β-Induced Tregs via Histone Modification but Not DNA Demethylation on Foxp3 Gene Locus

BACKGROUND: It has been documented all-trans retinoic acid (atRA) promotes the development of TGF-β-induced CD4(+)Foxp3(+) regulatory T cells (iTreg) that play a vital role in the prevention of autoimmune responses, however, molecular mechanisms involved remain elusive. Our objective, therefore, was...

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Autors principals: Lu, Ling, Ma, Jilin, Li, Zhiyuan, Lan, Qin, Chen, Maogen, Liu, Ya, Xia, Zanxian, Wang, Julie, Han, Yuanping, Shi, Wei, Quesniaux, Valerie, Ryffel, Bernhard, Brand, David, Li, Bin, Liu, Zhongmin, Zheng, Song Guo
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2011
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Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3172235/
https://ncbi.nlm.nih.gov/pubmed/21931768
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0024590
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