Antigen-specific TGF-β-induced regulatory T cells but not natural Tregs ameliorate autoimmune arthritis by shifting the balance of Th17 toward Treg cells

OBJECTIVE: Transferred CD4(+)CD25(+)Foxp3(+) regulatory cells (Tregs) can prevent autoimmune disease, but generally fail to ameliorate established disease. Here we demonstrate that antigen-specific Tregs induced with IL-2 and TGF-β ex-vivo (iTregs), but not equivalent expanded thymus-derived nTregs...

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Veröffentlicht in:Arthritis Rheum
Hauptverfasser: Kong, Ning, Lan, Qin, Chen, Maogen, Wang, Julie, Shi, Wei, Horwitz, David A, Quesniaux, Valerie, Ryffel, Bernhard, Liu, Zhongmin, Brand, David, Zou, Hejian, Zheng, Song Guo
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2012
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4364395/
https://ncbi.nlm.nih.gov/pubmed/22605463
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/art.34513
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