Disassembly of mitotic checkpoint complexes by the joint action of the AAA-ATPase TRIP13 and p31(comet)

The mitotic (or spindle assembly) checkpoint system delays anaphase until all chromosomes are correctly attached to the mitotic spindle. When the checkpoint is active, a Mitotic Checkpoint Complex (MCC) assembles and inhibits the ubiquitin ligase Anaphase-Promoting Complex/Cyclosome (APC/C). MCC is...

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Hoofdauteurs: Eytan, Esther, Wang, Kexi, Miniowitz-Shemtov, Shirly, Sitry-Shevah, Danielle, Kaisari, Sharon, Yen, Tim J., Liu, Song-Tao, Hershko, Avram
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: National Academy of Sciences 2014
Onderwerpen:
Biological Sciences
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4142996/
https://ncbi.nlm.nih.gov/pubmed/25092294
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1412901111
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