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Role of CCT chaperonin in the disassembly of mitotic checkpoint complexes

The mitotic checkpoint system prevents premature separation of sister chromatids in mitosis and thus ensures the fidelity of chromosome segregation. When this checkpoint is active, a mitotic checkpoint complex (MCC), composed of the checkpoint proteins Mad2, BubR1, Bub3, and Cdc20, is assembled. MCC...

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Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Kaisari, Sharon, Sitry-Shevah, Danielle, Miniowitz-Shemtov, Shirly, Teichner, Adar, Hershko, Avram
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2017
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5293070/
https://ncbi.nlm.nih.gov/pubmed/28096334
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1620451114
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