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Role of ubiquitylation of components of mitotic checkpoint complex in their dissociation from anaphase-promoting complex/cyclosome

The mitotic checkpoint system ensures the fidelity of chromosome segregation in mitosis by preventing premature initiation of anaphase until correct bipolar attachment of chromosomes to the mitotic spindle is reached. It promotes the assembly of a mitotic checkpoint complex (MCC), composed of BubR1,...

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Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Sitry-Shevah, Danielle, Kaisari, Sharon, Teichner, Adar, Miniowitz-Shemtov, Shirly, Hershko, Avram
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2018
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5828624/
https://ncbi.nlm.nih.gov/pubmed/29432156
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1720312115
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