ERα upregulates Phd3 to ameliorate HIF-1 induced fibrosis and inflammation in adipose tissue

Hypoxia Inducible Factor 1 (HIF-1) promotes fibrosis and inflammation in adipose tissues, while estrogens and Estrogen Receptor α (ERα) have the opposite effect. Here we identify an Estrogen Response Element (ERE) in the promoter of Phd3, which is a negative regulatory enzyme of HIF-1, and we demons...

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Detalhes bibliográficos
Main Authors: Kim, Min, Neinast, Michael D., Frank, Aaron P., Sun, Kai, Park, Jiyoung, Zehr, Jordan A., Vishvanath, Lavanya, Morselli, Eugenia, Amelotte, Mason, Palmer, Biff F., Gupta, Rana K., Scherer, Philipp E., Clegg, Deborah J.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2014
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4142394/
https://ncbi.nlm.nih.gov/pubmed/25161887
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molmet.2014.05.007
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