HIF-1α Upregulation due to Depletion of the Free Ubiquitin Pool

Hypoxia-inducible factor 1alpha (HIF-1α), which transactivates a variety of hypoxia-induced genes, is rapidly degraded under nomoxia through the hydroxylation-ubiquitination-proteasome pathway. In this study, we addressed how HIF-1α is stabilized by proteasome inhibitors. The ubiquitin pool was rapi...

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Bibliografiske detaljer
Udgivet i:J Korean Med Sci
Main Authors: Kim, Jiyoung, So, Daeho, Shin, Hyun-Woo, Chun, Yang-Sook, Park, Jong-Wan
Format: Artigo
Sprog:Inglês
Udgivet: The Korean Academy of Medical Sciences 2015
Fag:
Original Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4575926/
https://ncbi.nlm.nih.gov/pubmed/26425034
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3346/jkms.2015.30.10.1388
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