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HIF-1α Upregulation due to Depletion of the Free Ubiquitin Pool
Hypoxia-inducible factor 1alpha (HIF-1α), which transactivates a variety of hypoxia-induced genes, is rapidly degraded under nomoxia through the hydroxylation-ubiquitination-proteasome pathway. In this study, we addressed how HIF-1α is stabilized by proteasome inhibitors. The ubiquitin pool was rapi...
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| Udgivet i: | J Korean Med Sci |
|---|---|
| Main Authors: | , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
The Korean Academy of Medical Sciences
2015
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4575926/ https://ncbi.nlm.nih.gov/pubmed/26425034 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3346/jkms.2015.30.10.1388 |
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