An azido-oxazolidinone antibiotic for live bacterial cell imaging and generation of antibiotic variants

An azide-functionalised analogue of the oxazolidinone antibiotic linezolid was synthesised and shown to retain antimicrobial activity. Using facile ‘click’ chemistry, this versatile intermediate can be further functionalised to explore antimicrobial structure–activity relationships or conjugated to...

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Bibliografische gegevens
Hoofdauteurs: Phetsang, Wanida, Blaskovich, Mark A.T., Butler, Mark S., Huang, Johnny X., Zuegg, Johannes, Mamidyala, Sreeman K., Ramu, Soumya, Kavanagh, Angela M., Cooper, Matthew A.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Elsevier Science 2014
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4141890/
https://ncbi.nlm.nih.gov/pubmed/25023540
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2014.05.054
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