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An azido-oxazolidinone antibiotic for live bacterial cell imaging and generation of antibiotic variants
An azide-functionalised analogue of the oxazolidinone antibiotic linezolid was synthesised and shown to retain antimicrobial activity. Using facile ‘click’ chemistry, this versatile intermediate can be further functionalised to explore antimicrobial structure–activity relationships or conjugated to...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Elsevier Science
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4141890/ https://ncbi.nlm.nih.gov/pubmed/25023540 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2014.05.054 |
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