Regulation of the Interferon regulatory factor-8 (IRF-8) Tumor Suppressor Gene by the Signal Transducer and Activator of Transcription 5 (STAT5) Transcription Factor in Chronic Myeloid Leukemia

Tyrosine kinase inhibitors such as imatinib can effectively target the BCR-ABL oncoprotein in a majority of patients with chronic myeloid leukemia (CML). Unfortunately, some patients are resistant primarily to imatinib and others develop drug resistance, prompting interest in the discovery of new dr...

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Detalles Bibliográficos
Main Authors: Waight, Jeremy D., Banik, Debarati, Griffiths, Elizabeth A., Nemeth, Michael J., Abrams, Scott I.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Gene Regulation
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4140919/
https://ncbi.nlm.nih.gov/pubmed/24753251
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.544320
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