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The Granulocyte Progenitor Stage is a Key Target of IRF8-Mediated Regulation of Myeloid-Derived Suppressor Cell Production

Alterations in myelopoiesis are common across various tumor types, resulting in immature populations termed myeloid-derived suppressor cells (MDSCs). MDSC burden correlates with poorer clinical outcomes, credited to their ability to suppress antitumor immunity. MDSCs consist of two major subsets, mo...

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Detalhes bibliográficos
Publicado no:J Immunol
Main Authors: Netherby, Colleen S., Messmer, Michelle N., Burkard-Mandel, Lauren, Colligan, Sean, Miller, Austin, Gomez, Eduardo Cortez, Wang, Jianmin, Nemeth, Michael J., Abrams, Scott I.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5450940/
https://ncbi.nlm.nih.gov/pubmed/28356386
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1601722
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