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Structural Basis for the Recognition of Peptide RJPXD33 by Acyltransferases in Lipid A Biosynthesis

UDP-N-acetylglucosamine acyltransferase (LpxA) and UDP-3-O-(acyl)-glucosamine acyltransferase (LpxD) constitute the essential, early acyltransferases of lipid A biosynthesis. Recently, an antimicrobial peptide inhibitor, RJPXD33, was identified with dual affinity for LpxA and LpxD. To gain a fundame...

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Detalhes bibliográficos
Main Authors: Jenkins, Ronald J., Heslip, Kyle A., Meagher, Jennifer L., Stuckey, Jeanne A., Dotson, Garry D.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2014
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4140908/
https://ncbi.nlm.nih.gov/pubmed/24742680
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.564278
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