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DNA Damage Induces the Accumulation of Tiam1 by Blocking β-TrCP-dependent Degradation
The Rac1/JNK cascade plays important roles in DNA damage-induced apoptosis. However, how this cascade is activated upon DNA damage remains to be fully understood. We show here that, in untreated cells, Tiam1, a Rac1-specific guanine nucleotide exchange factor, is phosphorylated by casein kinase 1 (C...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4140904/ https://ncbi.nlm.nih.gov/pubmed/24737324 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.553388 |
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