Identification of 5′ AMP-activated Kinase as a Target of Reactive Aldehydes during Chronic Ingestion of High Concentrations of Ethanol

The production of reactive aldehydes including 4-hydroxy-2-nonenal (4-HNE) is a key component of the pathogenesis in a spectrum of chronic inflammatory hepatic diseases including alcoholic liver disease (ALD). One consequence of ALD is increased oxidative stress and altered β-oxidation in hepatocyte...

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Autores principales: Shearn, Colin T., Backos, Donald S., Orlicky, David J., Smathers-McCullough, Rebecca L., Petersen, Dennis R.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2014
Materias:
Lipids
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4140901/
https://ncbi.nlm.nih.gov/pubmed/24722988
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.543942
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