Inhibitory Phenotype of HBV-Specific CD4(+) T-Cells Is Characterized by High PD-1 Expression but Absent Coregulation of Multiple Inhibitory Molecules

BACKGROUND: T-cell exhaustion seems to play a critical role in CD8(+) T-cell dysfunction during chronic viral infections. However, up to now little is known about the mechanisms underlying CD4(+) T-cell dysfunction during chronic hepatitis B virus (CHB) infection and the role of inhibitory molecules...

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Main Authors: Raziorrouh, Bijan, Heeg, Malte, Kurktschiev, Peter, Schraut, Winfried, Zachoval, Reinhart, Wendtner, Clemens, Wächtler, Martin, Spannagl, Michael, Denk, Gerald, Ulsenheimer, Axel, Bengsch, Bertram, Pircher, Hanspeter, Diepolder, Helmut M., Grüner, Norbert H., Jung, Maria-Christina
Format: Artigo
Language:Inglês
Published: Public Library of Science 2014
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4140833/
https://ncbi.nlm.nih.gov/pubmed/25144233
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0105703
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