Dysfunctional CD8(+) T cells in hepatitis B and C are characterized by a lack of antigen-specific T-bet induction

The transcription factor T-bet regulates the production of interferon-γ and cytotoxic molecules in effector CD8 T cells, and its expression correlates with improved control of chronic viral infections. However, the role of T-bet in infections with differential outcome remains poorly defined. Here, w...

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Main Authors: Kurktschiev, Peter D., Raziorrouh, Bijan, Schraut, Winfried, Backmund, Markus, Wächtler, Martin, Wendtner, Clemens-Martin, Bengsch, Bertram, Thimme, Robert, Denk, Gerald, Zachoval, Reinhart, Dick, Andrea, Spannagl, Michael, Haas, Jürgen, Diepolder, Helmut M., Jung, Maria-Christina, Gruener, Norbert H.
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4172217/
https://ncbi.nlm.nih.gov/pubmed/25225458
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20131333
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