Lack of variant specific CD8+ T-cell response against mutant and pre-existing variants leads to outgrowth of particular clones in acute hepatitis C

BACKGROUND: CTL escape mutations have been described during acute hepatitis C in patients who developed chronic disease later on. Our aim was to investigate the mutual relationship between HCV specific CD8+ T cells and evolution of the viral sequence during early acute HCV infection. RESULTS: We seq...

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Detalhes bibliográficos
Main Authors: Ulsenheimer, Axel, Paranhos-Baccalà, Gláucia, Komurian-Pradel, Florence, Raziorrouh, Bijan, Kurktschiev, Peter, Diepolder, Helmut M, Zachoval, Reinhart, Spannagl, Michael, Jung, Maria-Christina, Gruener, Norbert H
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2013
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3849755/
https://ncbi.nlm.nih.gov/pubmed/24073713
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1743-422X-10-295
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