SH3BP2 Gain-Of-Function Mutation Exacerbates Inflammation and Bone Loss in a Murine Collagen-Induced Arthritis Model

OBJECTIVE: SH3BP2 is a signaling adapter protein which regulates immune and skeletal systems. Gain-of-function mutations in SH3BP2 cause cherubism, characterized by jawbone destruction. This study was aimed to examine the role of SH3BP2 in inflammatory bone loss using a collagen-induced arthritis (C...

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Main Authors: Mukai, Tomoyuki, Gallant, Richard, Ishida, Shu, Yoshitaka, Teruhito, Kittaka, Mizuho, Nishida, Keiichiro, Fox, David A., Morita, Yoshitaka, Ueki, Yasuyoshi
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4140794/
https://ncbi.nlm.nih.gov/pubmed/25144740
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0105518
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