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Loss of SH3BP2 function suppresses bone destruction in TNF-driven and collagen-induced arthritis mouse models
OBJECTIVE: SH3BP2 is a signaling adapter protein which regulates immune and skeletal systems. The purpose of this study was to investigate the role of SH3BP2 in arthritis in human TNF-α transgenic (hTNFtg) and collagen-induced arthritis (CIA) models. METHODS: First, SH3BP2-deficient (Sh3bp2(–/–)) an...
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| Publicado no: | Arthritis Rheumatol |
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| Main Authors: | , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4342302/ https://ncbi.nlm.nih.gov/pubmed/25470448 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/art.38975 |
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