A Parkinson's disease gene regulatory network identifies the signaling protein RGS2 as a modulator of LRRK2 activity and neuronal toxicity

Mutations in LRRK2 are one of the primary genetic causes of Parkinson's disease (PD). LRRK2 contains a kinase and a GTPase domain, and familial PD mutations affect both enzymatic activities. However, the signaling mechanisms regulating LRRK2 and the pathogenic effects of familial mutations rema...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Dusonchet, Julien, Li, Hu, Guillily, Maria, Liu, Min, Stafa, Klodjan, Derada Troletti, Claudio, Boon, Joon Y., Saha, Shamol, Glauser, Liliane, Mamais, Adamantios, Citro, Allison, Youmans, Katherine L., Liu, LiQun, Schneider, Bernard L., Aebischer, Patrick, Yue, Zhenyu, Bandopadhyay, Rina, Glicksman, Marcie A., Moore, Darren J., Collins, James J., Wolozin, Benjamin
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2014
Assuntos:
Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4140468/
https://ncbi.nlm.nih.gov/pubmed/24794857
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddu202
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados