A Parkinson's disease gene regulatory network identifies the signaling protein RGS2 as a modulator of LRRK2 activity and neuronal toxicity

Mutations in LRRK2 are one of the primary genetic causes of Parkinson's disease (PD). LRRK2 contains a kinase and a GTPase domain, and familial PD mutations affect both enzymatic activities. However, the signaling mechanisms regulating LRRK2 and the pathogenic effects of familial mutations rema...

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Hlavní autoři: Dusonchet, Julien, Li, Hu, Guillily, Maria, Liu, Min, Stafa, Klodjan, Derada Troletti, Claudio, Boon, Joon Y., Saha, Shamol, Glauser, Liliane, Mamais, Adamantios, Citro, Allison, Youmans, Katherine L., Liu, LiQun, Schneider, Bernard L., Aebischer, Patrick, Yue, Zhenyu, Bandopadhyay, Rina, Glicksman, Marcie A., Moore, Darren J., Collins, James J., Wolozin, Benjamin
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2014
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4140468/
https://ncbi.nlm.nih.gov/pubmed/24794857
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddu202
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