PCTAIRE Kinase 3/Cyclin-dependent Kinase 18 Is Activated through Association with Cyclin A and/or Phosphorylation by Protein Kinase A

PCTAIRE kinase 3 (PCTK3)/cyclin-dependent kinase 18 (CDK18) is an uncharacterized member of the CDK family because its activator(s) remains unidentified. Here we describe the mechanisms of catalytic activation of PCTK3 by cyclin A2 and cAMP-dependent protein kinase (PKA). Using a pulldown experiment...

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Bibliographic Details
Main Authors: Matsuda, Shinya, Kominato, Kyohei, Koide-Yoshida, Shizuyo, Miyamoto, Kenji, Isshiki, Kinuka, Tsuji, Akihiko, Yuasa, Keizo
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2014
Subjects:
Signal Transduction
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4140294/
https://ncbi.nlm.nih.gov/pubmed/24831015
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.542936
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