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Leucine-rich repeat kinase 2 (LRRK2) regulates inflammatory bowel disease through the Nuclear Factor of Activated T cells (NFAT)
Leucine-rich repeat kinase 2 (LRRK2), implicated in familial Parkinson’s disease (PD), was recently identified as a major susceptibility gene for Crohn’s disease (CD) by genome-wide association studies (GWAS). We found that LRRK2 deficiency confers enhanced susceptibility to experimental colitis in...
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| 主要な著者: | , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2011
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4140245/ https://ncbi.nlm.nih.gov/pubmed/21983832 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.2113 |
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