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Generation of a high-titer retroviral vector capable of expressing high levels of the human beta-globin gene.

Retrovirus-mediated gene transfer into hematopoietic cells may provide a means of treating both inherited and acquired diseases involving hematopoietic cells. Implementation of this approach for disorders resulting from mutations affecting the beta-globin gene (e.g., beta-thalassemia and sickle cell...

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Detalhes bibliográficos
Main Authors: Sadelain, M, Wang, C H, Antoniou, M, Grosveld, F, Mulligan, R C
Formato: Artigo
Idioma:Inglês
Publicado em: 1995
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC41402/
https://ncbi.nlm.nih.gov/pubmed/7624311
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