ROS1 and ALK Fusions in Colorectal Cancer, with Evidence of Intra-tumoral Heterogeneity for Molecular Drivers

Activated ALK and ROS1 tyrosine kinases, through gene fusions, has been found in lung adenocarcinomas and are highly sensitive to selective kinase inhibitors. This study aimed at identifying the presence of these rearrangements in human colorectal adenocarcinoma (CRC) specimens using a 4-target, 4-c...

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Autores principales: Aisner, Dara L., Nguyen, Teresa T., Paskulin, Diego D., Le, Anh T., Haney, Jerry, Schulte, Nathan, Chionh, Fiona, Hardingham, Jenny, Mariadason, John, Tebbutt, Niall, Doebele, Robert C., Weickhardt, Andrew J., Varella-Garcia, Marileila
Formato: Artigo
Lenguaje:Inglês
Publicado: 2013
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4140177/
https://ncbi.nlm.nih.gov/pubmed/24296758
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-13-0479-T
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