Native and rearranged ALK copy number and rearranged cell count in NSCLC: Implications for ALK inhibitor therapy

BACKGROUND: Anaplastic Lymphoma Kinase positive (ALK+) non-small cell lung cancer (NSCLC) responds to ALK inhibitors. Clinically, ≥ 15% cells showing rearrangements by break-apart FISH classify tumors as positive. Increases in native and rearranged ALK copy number also occur. METHODS: 1426 NSCLC cli...

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Hauptverfasser: Camidge, D. Ross, Skokan, Margaret, Kiatsimkul, Porntip, Helfrich, Barbara, Lu, Xian, Barón, Anna E., Schulte, Nathan, Maxson, DeLee, Aisner, Dara L., Franklin, Wilbur A., Doebele, Robert C., Varella-Garcia, Marileila
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2013
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3947483/
https://ncbi.nlm.nih.gov/pubmed/24022839
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cncr.28311
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