Mechanisms of Resistance to Crizotinib in Patients with ALK Gene Rearranged Non-Small Cell Lung Cancer

PURPOSE: Patients with anaplastic lymphoma kinase (ALK) gene rearrangements often manifest dramatic responses to crizotinib, a small molecule ALK inhibitor. Unfortunately, not every patient responds and acquired drug resistance inevitably develops in those that do respond. This study aimed to define...

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Autori principali: Doebele, Robert C., Pilling, Amanda B., Aisner, Dara L., Kutateladze, Tatiana G., Le, Anh T., Weickhardt, Andrew J., Kondo, Kimi L., Linderman, Derek, Heasley, Lynn E., Franklin, Wilbur A., Varella-Garcia, Marileila, Camidge, D. Ross
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2012
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3311875/
https://ncbi.nlm.nih.gov/pubmed/22235099
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-11-2906
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