Correlations between the percentage of tumor cells showing an ALK gene rearrangement, ALK signal copy number and response to crizotinib therapy in ALK FISH positive non-small cell lung cancer

BACKGROUND: FISH, using break-apart red (3’) and green (5’) ALK probes, consistently shows rearrangements in < 100% of tumor cells in ALK+ NSCLC. Increased copy numbers of fused and rearranged signals also occur. Here we explore correlations between the percentage of ALK positive cells and signal...

Full beskrivning

Sparad:
Bibliografiska uppgifter
Huvudupphovsmän: Camidge, D. Ross, Theodoro, Mariana, Maxson, DeLee A., Skokan, Margaret, O’Brien, Tara, Lu, Xian, Doebele, Robert C., Barón, Anna E., Varella-Garcia, Marileila
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2012
Ämnen:
Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3342464/
https://ncbi.nlm.nih.gov/pubmed/22282074
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cncr.27411
Taggar: Lägg till en tagg
Inga taggar, Lägg till första taggen!

Liknande verk