Correlations between the percentage of tumor cells showing an ALK gene rearrangement, ALK signal copy number and response to crizotinib therapy in ALK FISH positive non-small cell lung cancer

BACKGROUND: FISH, using break-apart red (3’) and green (5’) ALK probes, consistently shows rearrangements in < 100% of tumor cells in ALK+ NSCLC. Increased copy numbers of fused and rearranged signals also occur. Here we explore correlations between the percentage of ALK positive cells and signal...

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Main Authors: Camidge, D. Ross, Theodoro, Mariana, Maxson, DeLee A., Skokan, Margaret, O’Brien, Tara, Lu, Xian, Doebele, Robert C., Barón, Anna E., Varella-Garcia, Marileila
Format: Artigo
Sprog:Inglês
Udgivet: 2012
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3342464/
https://ncbi.nlm.nih.gov/pubmed/22282074
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cncr.27411
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