Optimizing the Detection of Lung Cancer Patients Harboring Anaplastic Lymphoma Kinase (ALK) Gene Rearrangements Potentially Suitable for ALK Inhibitor Treatment

PURPOSE: Anaplastic lymphoma kinase (ALK) rearrangements, associated with sensitivity to an experimental ALK/MET inhibitor, occur in 3% to 5% of non-small cell lung cancers. Intratumoral fluorescence in situ hybridization (FISH) heterogeneity has been reported. We explored the heterogeneity basis, t...

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Hauptverfasser: Camidge, D. Ross, Kono, Scott A., Flacco, Antonella, Tan, Aik-Choon, Doebele, Robert C., Zhou, Qing, Crino, Lucio, Franklin, Wilbur A., Varella-Garcia, Marileila
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2010
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3395226/
https://ncbi.nlm.nih.gov/pubmed/21062932
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-10-0851
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