Resistance mechanisms to targeted therapies in ROS1+ and ALK+ non-small cell lung cancer

PURPOSE: Despite initial benefit from tyrosine kinase inhibitors (TKI), advanced non-small cell lung cancer (NSCLC) patients harboring ALK (ALK+) and ROS1 (ROS1+) gene fusions ultimately progress. Here we report on the potential resistance mechanisms in a series of ALK+ and ROS1+ NSCLC patients prog...

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Udgivet i:Clin Cancer Res
Main Authors: McCoach, Caroline E., Le, Anh T., Gowan, Katherine, Jones, Kenneth, Schubert, Laura, Doak, Andrea, Estrada-Bernal, Adriana, Davies, Kurtis D., Merrick, Daniel T., Bunn, Paul A., Purcell, W. Tom, Dziadziuszko, Rafal, Varella-Garcia, Marileila, Aisner, Dara L., Camidge, D. Ross, Doebele, Robert C.
Format: Artigo
Sprog:Inglês
Udgivet: 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6050099/
https://ncbi.nlm.nih.gov/pubmed/29636358
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-17-2452
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